PLOS ONE Transcriptomic Analysis of Brown Adipose Tissue across the Physiological… — Volkswagen Pointer Variant II

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Transcriptomic Analysis of Brown Tissue across the Physiological of Natural Hibernation

Marshall


Affiliation: Department of Mathematics and University of Minnesota Duluth, Minnesota, United States of

Abstract

We used RNAseq to a comprehensive transcriptome of Brown Tissue (BAT) over the of a year in the naturally hibernating ground squirrel, Ictidomys . During hibernation ground do not feed and use fat stored in White Tissue (WAT) as their source of fuel. Stored is consumed at high rates by BAT to heat at specific points the hibernation season. The highest of BAT activity occurs during arousals from hypothermic bouts, referred to as Interbout (IBAs). IBAs are characterized by body re-warming (from 5 to 37 °C) in 2-3 and provide a unique opportunity to the genes responsible for the highly lipid oxidation and heat that drives the …process. HighSeq sequencing identified distinct BAT mRNAs and quantified levels at four points: ground squirrels in April and and hibernating animals during torpor and IBA. Based on changes in mRNA levels the four collection points, genes were shown to be expressed. In addition to

providing detail on the expression of genes encoding mitochondrial and genes involved in beta-adrenergic and pathways, we identified differentially genes encoding various factors and other regulatory which may play critical in high efficiency fat catabolism, thermogenesis, and transitions into and out of the state.

Citation: Hampton M, Melvin RG, MT (2013) Transcriptomic Analysis of Adipose Tissue across the Extremes of Natural Hibernation. ONE 8(12): e85157. doi:10.1371/journal.pone.0085157

Karin Dahlman-Wright, Karolinska Sweden

Volkswagen Pointer Variant II

Received: July 23, Accepted: November 23, 2013; December 30, 2013

Copyright: © Hampton et al. This is an open-access distributed under the terms of the Commons Attribution License. permits unrestricted use, and reproduction in any medium, provided the author and source are credited.

Funding: This work was byNational Institutes of Health 1RC2HL101625-01 to MTA. The funders had no in study design, data and analysis, decision to publish, or of the manuscript.

Competing interests: The have declared that no interests exist.

Introduction

all mammals possess Brown Tissue (BAT) as infants to maintain their body through nonshivering thermogenesis. White Adipose Tissue which serves as the main fat depot in children and adults, BAT has to generate heat in newborn and mammals (reviewed in [1 ]). Mammals hibernate retain BAT as adults in to efficiently re-warm themselves arousing from hypothermic The discovery of BAT in … humans [2 -5 ] has excitement in the biomedical community of its potential for accelerating weight in obese individuals [6 -8 ]. However little is known about the required for optimal BAT function.

In this study we examined BAT expression in a naturally hibernating the thirteen-lined ground squirrel ( tridecemlineatus ). During 5 months of these animals do not eat and use fat stores as primary source of fuel. lipid is consumed at high by BAT to generate heat at specific during the hibernation season. The rate of BAT activity occurs multiple arousals from torpor bouts referred to as Arousals (IBAs). IBAs every 1-2 weeks and are characterized by whole body re-warming and a of normothermic metabolic activity for hours (Figure 1 ). IBAs provide a unique opportunity to the molecular factors in BAT that are for the highly efficient fat burning that drives the …process. the 2-3 hour transition out of torpor, O 2 increases 50-fold, heart explodes from less

than 10 beats per minute to over 400 bpm, and body increases from 5 to 37°C [9 ].

Volkswagen Pointer Variant II
Volkswagen Pointer Variant II
Volkswagen Pointer Variant II
Volkswagen Pointer Variant II

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